What is claimed, and what is supported
These are two different lists. Putting them side by side is the entire purpose of this page, and it is the part a sales page never does.
The label claims advanced memory support and the sales page names cognitive function and mental clarity. Both are structure/function claims, which need no pre-market review.
Four of the twenty-two named ingredients have a cognitive literature worth describing. Two of those four can reach the bottom of their studied range here. The other two miss by 155× and 6,787×.
What the label and sales page claim
- Advanced memory support — printed on the bottle front, with the FDA disclaimer asterisk.
- Cognitive function and mental clarity — the language the sales page uses, per the brief supplied to this site.
That is the whole of it. Two claims, both structure/function, both carrying the disclaimer. Nobody is claiming this treats anything, and credit where it is due: the label does not overreach.
What a structure/function claim is
A statement that a nutrient affects a structure or function of the body. It does not require pre-market approval. The manufacturer must hold substantiation, notify the FDA within thirty days of first marketing, and print the disclaimer. None of that involves the agency reviewing the evidence, and a buyer never sees the substantiation file.
What the research on these ingredients found
Four of the twenty-two names have human evidence worth describing for a cognitive outcome. Here is what those studies found, and at what dose.
| Ingredient | What was found | At what dose | Ceiling here |
|---|---|---|---|
| Panax ginseng | A 2024 systematic review found improvements on some cognitive measures in healthy and impaired adults, with heterogeneous designs | 200 to 400 mg a day of standardised extract | 1.29 mg |
| Guarana | A 2023 meta-analysis found a statistically significant but, in its own words, less than trivial pooled effect on cognition | 37.5 to 500 mg a day | 77.4 mg raw equivalent |
| L-tyrosine | Improved working memory under acute stress in military and cold-exposure trials | About 100 mg per kilogram, roughly 7 g for a 70 kg adult | 1.03 mg |
| Grape seed extract | A 2016 trial found effects on attention and memory measures in healthy older adults | 100 to 2,000 mg a day | 103 mg raw equivalent |
Scroll this table sideways →
Two of those four ceilings clear the bottom of the studied range once the extract ratio is granted. The other two miss by 155-fold and 6,787-fold. That is the honest summary of the cognitive evidence on this label.
The gap, stated plainly
Sixteen of the twenty-one blend ingredients have a researched human dose we could verify and cite. Fourteen of those sixteen cannot reach it, on a reading that grants the maximum ceiling and the full extract ratio at the same time. Two can. Five have no verifiable human dose to compare against at all.
This does not mean nobody will notice anything. Guarana carries caffeine, caffeine is noticeable, and expectation is a real and well-documented effect. It means that if something is noticed, the label gives no basis for attributing it to the twenty ingredients that are not guarana.
The benefits a product like this genuinely has
A daily ritual
A morning habit attached to a bottle is a real behavioural intervention, and the reviews the seller published say the daily serving is what people liked most.
A decision made
Choosing something and running it for a month beats an open loop of research that never resolves. That has value even when the formula does not.
A long return window
180 days on the sales page kits is longer than the trials behind most of these ingredients. Whatever else is true, the buyer carries less risk than usual.
Those three are real and this site is not going to pretend otherwise. They are also not what the label is selling, and none of them requires twenty-one botanical extracts.
What we would need to change this page
- A published split of the blend showing any ingredient at a researched dose.
- A standardisation figure for any extract on the label.
- A human trial of the finished formula.
- A certificate of analysis with measured content.
Send any of those to [email protected] and this page changes the same week. We would publish a correction with the date on it, as we would for any error of our own.
See the Cognizil packs
Two, three or six bottles, priced plainly, with a 180-day window on the sales page kits. Read the best case first, then decide.
Shipping is calculated at checkout. This site publishes no figure it was not given.
References
Every source below was opened and read. Nothing here cites a study we did not read, and no identifier on this site was written from memory.
- U.S. Government Publishing Office21 CFR 101.36 — Nutrition labeling of dietary supplements — eCFR.gov · source
- U.S. Food and Drug AdministrationDietary Supplement Labeling Guide: Chapter IV, Nutrition Labeling — FDA.gov · source
- U.S. Food and Drug AdministrationDaily Value and Percent Daily Value: Changes on the New Nutrition and Supplement Facts Labels — FDA.gov · source
- U.S. Food and Drug AdministrationGrapefruit Juice and Some Drugs Don’t Mix — FDA.gov · source
- U.S. Food and Drug AdministrationFDA Calls on Certain Firms to Stop Producing and Issuing Misleading ‘FDA Registration Certificates’ — FDA.gov · source
- Booker, Frommenwiler, Reich et al. — 2022Understanding plant to extract ratios in botanical extracts — Frontiers in Pharmacology · DOI 10.3389/fphar.2022.981978 · source
- Shin, Lee, Yang, Lim & Ernst — 2010Maca (L. meyenii) for improving sexual function: a systematic review — BMC Complementary and Alternative Medicine · PMID 20691074 · source
- Ngondi, Etoundi, Nyangono et al. — 2009IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans — Lipids in Health and Disease · PMID 19254366 · source
- Centre for Reviews and DisseminationThe efficacy of Irvingia gabonensis supplementation in the management of overweight and obesity: a systematic review of randomized controlled trials — NCBI Bookshelf (DARE) · NBK132337 · source
- Zhang, Liu, Li et al. — 2016The impact of grape seed extract treatment on blood pressure changes: a meta-analysis of 16 randomized controlled trials — Medicine (Baltimore) · PMID 27537554 · source
- Congretel, Bonnet, Gaudel et al. — 2023Effect of Guarana (Paullinia cupana) on Cognitive Performance: A Systematic Review and Meta-Analysis — Nutrients · PMID 36678305 · source
- European Medicines Agency, Committee on Herbal Medicinal ProductsAssessment report on Eleutherococcus senticosus (Rupr. et Maxim.) Maxim., radix — ema.europa.eu · source
- Schaffler, Wolf & Burkart — 2013No benefit adding Eleutherococcus senticosus to stress management training in stress-related fatigue/weakness, impaired work or concentration — Pharmacopsychiatry · PMID 23740477 · source
- Pop, Cherecheș, Buzoianu et al. — 2021Standardized astragalus extract for attenuation of the immunosuppression induced by strenuous physical exercise: randomized controlled trial — Journal of the International Society of Sports Nutrition · PMID 34271953 · source
- Zhang, Lin, Xu, Leung & Chan — 2014Astragalus (a traditional Chinese medicine) for treating chronic kidney disease — Cochrane Database of Systematic Reviews · CD008369.pub2 · source
- European Food Safety Authority — 2018Scientific opinion on the safety of green tea catechins — EFSA Journal · DOI 10.2903/j.efsa.2018.5239 · source
- National Institute of Diabetes and Digestive and Kidney DiseasesGymnema, in LiverTox: Clinical and Research Information on Drug-Induced Liver Injury — NCBI Bookshelf · NBK610217 · source
- Godard, Johnson & Richmond — 2005Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men — Obesity Research · PMID 16129715 · source
- Henderson, Magu, Rasmussen et al. — 2005Effects of Coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women — Journal of the International Society of Sports Nutrition · PMID 18500958 · source
- Zsiborás, Matics, Hegedűs et al. — 2023The effects of capsaicin intake on weight loss among overweight and obese subjects: a systematic review and meta-analysis of randomised controlled trials — British Journal of Nutrition · PMID 36938807 · source
- Takeoka, Dao, Wong, Lundin & Mahoney — 2001Identification of benzethonium chloride in commercial grapefruit seed extracts — Journal of Agricultural and Food Chemistry · PMID 11453769 · source
- Avula, Dentali & Khan — 2007Simultaneous identification and quantification by liquid chromatography of benzethonium chloride, methyl paraben and triclosan in commercial products labeled as grapefruit seed extract — Die Pharmazie · PMID 17867553 · source
- Zeng, Li, Wang et al. — 2024Effects of Ginseng on Cognitive Function: A Systematic Review and Meta-Analysis — Phytotherapy Research · PMID 39474788 · source
- Operational Supplement Safety, Consortium for Health and Military PerformanceRaspberry ketone dietary supplements for weight loss — opss.org · source
- Gleeson — 2008Dosing and efficacy of glutamine supplementation in human exercise and sport training — Journal of Nutrition · PMID 18806122 · source
- Deijen & Orlebeke — 1994Effect of tyrosine on cognitive function and blood pressure under stress — Brain Research Bulletin · PMID 8293316 · source
- McNeal, Meininger, Wilborn et al. — 2018Safety of dietary supplementation with arginine in adult humans — Amino Acids · PMID 29858688 · source
- Collier, Casey & Kanaley — 2005Growth hormone responses to varying doses of oral arginine — Growth Hormone & IGF Research · PMID 15809017 · source
- Trexler, Smith-Ryan, Stout et al. — 2015International Society of Sports Nutrition position stand: Beta-Alanine — Journal of the International Society of Sports Nutrition · PMID 26175657 · source
- Joint FAO/WHO Expert Committee on Food AdditivesGlycyrrhizinic acid — evaluation and intake guidance — WHO JECFA database · source
- Hepsomali, Groeger, Nishihira & Scholey — 2020Effects of oral gamma-aminobutyric acid (GABA) administration on stress and sleep in humans: a systematic review — Frontiers in Neuroscience · DOI 10.3389/fnins.2020.00923 · source
- Sutanto, Loh, Kim & Kim — 2021The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression — Nutrition Reviews · PMID 33942088 · source
- NIH Office of Dietary SupplementsCarnitine — Health Professional Fact Sheet — ods.od.nih.gov · source
- NIH Office of Dietary SupplementsChromium — Health Professional Fact Sheet — ods.od.nih.gov · source
- U.S. Food and Drug AdministrationQuestions and Answers on Dietary Supplements — FDA.gov · source