Who it is for
Most product sites answer this with a list of flattering descriptions. The more useful version has three parts: who the label excludes, who should talk to a clinician first, and who is left.
Who the label excludes
The label states: not for use by individuals under the age of 18, or by women who are pregnant or nursing. Those are the manufacturer's own exclusions and this site repeats them without qualification.
- Anyone under 18. Stated on the label.
- Pregnant or nursing. Stated on the label.
- Anyone with a known allergy to a listed ingredient. The Other Ingredients line includes natural flavors and citrus extract, neither of which is specified.
There is no discretion in this section. It is what the bottle says.
Who should speak to a clinician first
This list is longer than the label's, because the label does not name interactions and several ingredients here have well-documented ones.
| If you | Because |
|---|---|
| Take a statin, a calcium channel blocker or an immunosuppressant | Grapefruit is a well-documented CYP3A4 interaction. The amount here is bounded small, and the class of interaction is serious enough to raise. |
| Take medication for blood sugar | Gymnema and forskolin are both studied for glucose handling. Bounded small here, worth a mention. |
| Take a blood pressure medicine | Forskolin and licorice derivatives both have blood pressure literature, in opposite directions. |
| Take an antidepressant, particularly an SSRI or MAOI | L-tryptophan and L-tyrosine are both precursors in monoamine pathways. |
| Are caffeine-sensitive or avoid caffeine | Guarana is on the list and the caffeine content is not stated. |
| Have a thyroid condition | Tyrosine is a thyroid hormone precursor. |
| Have liver disease or take a hepatotoxic drug | Green tea extract and gymnema both have case reports of liver injury at far higher intakes than this label can deliver. |
| Have an autoimmune condition | Astragalus and eleuthero are traditionally described as immune-active. |
Why the list is long when the doses are small
Every one of these is bounded by the 15.47 mg total, so the practical risk from this product is low. The reason to raise them anyway is that a clinician needs to know what you are taking, not what you calculated it probably contains. Hand them the label.
Who is left
Someone who wants a daily habit and has read this site
If you have read the best-case page, understand that the blend is 15.47 mg across twenty-one names, and want to run a thirty-day trial on yourself anyway, that is a decision made with the facts in hand. It is not our place to argue with it.
Someone buying on the guarantee
180 days is a long window. A buyer who intends to use it, and who keeps the order email and a note of the delivery date, carries very little financial risk.
Someone who would otherwise buy nothing and change nothing
The weakest argument on this page and we are including it anyway. A bottle that gets someone paying attention to sleep and routine has done something, even if the formula did not.
Someone comparison-shopping honestly
If you came here to compare this against a single-ingredient product at a disclosed dose, the comparison is straightforward and this site has given you everything you need to make it.
Notice that none of those four is "someone looking to improve their memory". That claim requires a dose, and the dose is the thing this label does not publish.
Who should skip it
- Anyone expecting a specific ingredient at a researched dose. Buy that ingredient on its own, at a disclosed milligram figure, for less.
- Anyone treating this as an alternative to a clinical assessment for memory changes that worry them. Memory change has causes worth identifying, and several of them are treatable.
- Anyone who will not read the label. Twenty-two names and one quantified line is not a product you can buy on the front panel.
- Anyone on a tight budget who has not costed it. $49 to $79 a bottle for 15.47 mg of blend is the arithmetic to sit with before ordering, not after.
If you are in the first group, the ingredients page lists what each name was studied at. Any of those is available on its own, quantified, and usually for less than a bottle of this.
The age question
The reviews the seller published skew older: the named ages run from 41 to 65, with a median in the late fifties. That is the audience this is marketed to, and it is the audience for whom the advice to see a clinician about memory change matters most.
Age-related memory change and a treatable cause are not distinguishable from the inside. Thyroid function, B12 status, sleep apnoea, medication side effects and depression all present this way and all have treatments. A supplement bought instead of that conversation is the one real harm a product like this can do.
See the Cognizil packs
Two, three or six bottles, priced plainly, with a 180-day window on the sales page kits. Read the best case first, then decide.
Shipping is calculated at checkout. This site publishes no figure it was not given.
References
Every source below was opened and read. Nothing here cites a study we did not read, and no identifier on this site was written from memory.
- U.S. Government Publishing Office21 CFR 101.36 — Nutrition labeling of dietary supplements — eCFR.gov · source
- U.S. Food and Drug AdministrationDietary Supplement Labeling Guide: Chapter IV, Nutrition Labeling — FDA.gov · source
- U.S. Food and Drug AdministrationDaily Value and Percent Daily Value: Changes on the New Nutrition and Supplement Facts Labels — FDA.gov · source
- U.S. Food and Drug AdministrationGrapefruit Juice and Some Drugs Don’t Mix — FDA.gov · source
- U.S. Food and Drug AdministrationFDA Calls on Certain Firms to Stop Producing and Issuing Misleading ‘FDA Registration Certificates’ — FDA.gov · source
- Booker, Frommenwiler, Reich et al. — 2022Understanding plant to extract ratios in botanical extracts — Frontiers in Pharmacology · DOI 10.3389/fphar.2022.981978 · source
- Shin, Lee, Yang, Lim & Ernst — 2010Maca (L. meyenii) for improving sexual function: a systematic review — BMC Complementary and Alternative Medicine · PMID 20691074 · source
- Ngondi, Etoundi, Nyangono et al. — 2009IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans — Lipids in Health and Disease · PMID 19254366 · source
- Centre for Reviews and DisseminationThe efficacy of Irvingia gabonensis supplementation in the management of overweight and obesity: a systematic review of randomized controlled trials — NCBI Bookshelf (DARE) · NBK132337 · source
- Zhang, Liu, Li et al. — 2016The impact of grape seed extract treatment on blood pressure changes: a meta-analysis of 16 randomized controlled trials — Medicine (Baltimore) · PMID 27537554 · source
- Congretel, Bonnet, Gaudel et al. — 2023Effect of Guarana (Paullinia cupana) on Cognitive Performance: A Systematic Review and Meta-Analysis — Nutrients · PMID 36678305 · source
- European Medicines Agency, Committee on Herbal Medicinal ProductsAssessment report on Eleutherococcus senticosus (Rupr. et Maxim.) Maxim., radix — ema.europa.eu · source
- Schaffler, Wolf & Burkart — 2013No benefit adding Eleutherococcus senticosus to stress management training in stress-related fatigue/weakness, impaired work or concentration — Pharmacopsychiatry · PMID 23740477 · source
- Pop, Cherecheș, Buzoianu et al. — 2021Standardized astragalus extract for attenuation of the immunosuppression induced by strenuous physical exercise: randomized controlled trial — Journal of the International Society of Sports Nutrition · PMID 34271953 · source
- Zhang, Lin, Xu, Leung & Chan — 2014Astragalus (a traditional Chinese medicine) for treating chronic kidney disease — Cochrane Database of Systematic Reviews · CD008369.pub2 · source
- European Food Safety Authority — 2018Scientific opinion on the safety of green tea catechins — EFSA Journal · DOI 10.2903/j.efsa.2018.5239 · source
- National Institute of Diabetes and Digestive and Kidney DiseasesGymnema, in LiverTox: Clinical and Research Information on Drug-Induced Liver Injury — NCBI Bookshelf · NBK610217 · source
- Godard, Johnson & Richmond — 2005Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men — Obesity Research · PMID 16129715 · source
- Henderson, Magu, Rasmussen et al. — 2005Effects of Coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women — Journal of the International Society of Sports Nutrition · PMID 18500958 · source
- Zsiborás, Matics, Hegedűs et al. — 2023The effects of capsaicin intake on weight loss among overweight and obese subjects: a systematic review and meta-analysis of randomised controlled trials — British Journal of Nutrition · PMID 36938807 · source
- Takeoka, Dao, Wong, Lundin & Mahoney — 2001Identification of benzethonium chloride in commercial grapefruit seed extracts — Journal of Agricultural and Food Chemistry · PMID 11453769 · source
- Avula, Dentali & Khan — 2007Simultaneous identification and quantification by liquid chromatography of benzethonium chloride, methyl paraben and triclosan in commercial products labeled as grapefruit seed extract — Die Pharmazie · PMID 17867553 · source
- Zeng, Li, Wang et al. — 2024Effects of Ginseng on Cognitive Function: A Systematic Review and Meta-Analysis — Phytotherapy Research · PMID 39474788 · source
- Operational Supplement Safety, Consortium for Health and Military PerformanceRaspberry ketone dietary supplements for weight loss — opss.org · source
- Gleeson — 2008Dosing and efficacy of glutamine supplementation in human exercise and sport training — Journal of Nutrition · PMID 18806122 · source
- Deijen & Orlebeke — 1994Effect of tyrosine on cognitive function and blood pressure under stress — Brain Research Bulletin · PMID 8293316 · source
- McNeal, Meininger, Wilborn et al. — 2018Safety of dietary supplementation with arginine in adult humans — Amino Acids · PMID 29858688 · source
- Collier, Casey & Kanaley — 2005Growth hormone responses to varying doses of oral arginine — Growth Hormone & IGF Research · PMID 15809017 · source
- Trexler, Smith-Ryan, Stout et al. — 2015International Society of Sports Nutrition position stand: Beta-Alanine — Journal of the International Society of Sports Nutrition · PMID 26175657 · source
- Joint FAO/WHO Expert Committee on Food AdditivesGlycyrrhizinic acid — evaluation and intake guidance — WHO JECFA database · source
- Hepsomali, Groeger, Nishihira & Scholey — 2020Effects of oral gamma-aminobutyric acid (GABA) administration on stress and sleep in humans: a systematic review — Frontiers in Neuroscience · DOI 10.3389/fnins.2020.00923 · source
- Sutanto, Loh, Kim & Kim — 2021The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression — Nutrition Reviews · PMID 33942088 · source
- NIH Office of Dietary SupplementsCarnitine — Health Professional Fact Sheet — ods.od.nih.gov · source
- NIH Office of Dietary SupplementsChromium — Health Professional Fact Sheet — ods.od.nih.gov · source
- U.S. Food and Drug AdministrationQuestions and Answers on Dietary Supplements — FDA.gov · source